Generating, measuring, and modeling biological assembliers in 2D and 3D
Goals
1. Surface assembly of collagens - Students will learn how to grow collagen fibrils into ordered networks and image them by using atomic force microscopy. Based on this foundation, we will create ordered collagen layers of tailored properties to emulate assembly and remodeling processes of
collagen in human tissues. 2. Multiscalre modeling and analysis - Learn and perform advanced biomolecular computing including: model construction, simulation, and analysis of biomolecular and meso-scale biological structures. Use them to analyze systems such as molecular motors, biopolymer systems, and braiin development in animal embryos.
Issues Involved or Addressed
Better understand numerous collagen-associated diseases or processes including cancer and wound healing. Development of novel biomimetics with nanoscale order. Modeling and simulation development for better therapeutic and pharmaceutical strategies.
